This chapter explores the current political economy of unequal financial and economic relation between the core, or the North, constituting many former colonial metropoles, and the periphery, or Global South, and former colonies. This is attempted through a dynamic and dialectical weaving of two disciplinary approaches, that of the colonial production of knowledge within decolonial theory with the dependency theory framework that articulates on financial dependency and disciplinary mechanisms systemically embedded into the global financial-economic architecture.