This paper requests to share reflections, tensions and intentions that the decolonial thought can provide in the studies on gender and science, meaning a possible movement of insubmission capable of fortification the feminist critique of science. In this, the ideas are produced by the bibliographical research on decolonial thinking in contrast with a trajectory of previous researches on gender discrimination in the universities and Policy of Science, Technology & Innovation in the Northeast of Brazil. As a principal contribution, it puts epistemic disobedience as necessary to feminist critique - as contraposition to sexism only in an abstract way, but to understand it as an inseparable part of racial, ethnic, economic, and epistemic relations.